Guidance on value assigning the purity of organic pure materials using quantitative nuclear magnetic resonance (qNMR) is now available through the BIPM e-learning platform. qNMR is becoming the method of choice for the value assignment of purity of organic compounds as primary reference materials for diagnostic, food safety, pharmaceutical, forensic and drug testing and other applications.

The e-learning course material is suitable for those at NMIs and DIs who already have experience in NMR instrument operation and data acquisition. It will will allow them to enhance their knowledge and skills in the use of qNMR techniques for value assignment of pure organic materials.

The modules are based on lectures and practical activities included in the first BIPM Summer School on qNMR measurement techniques in June 2024. These cover gravimetric preparation of samples for qNMR; use of NMR software for quantification; spectrometer set up for ¹H qNMR; Internal Substance Reference Materials and Reference Data for qNMR; FID processing, baseline correction, deconvolution and integration of spectra; qNMR data correction using LC information; qNMR applied to peptides; spectrometer set up for ¹⁹F and ³¹P qNMR; measurement uncertainty calculation for qNMR; 2D NMR – structure confirmation and impurity profiling.