Atelier du CCQM: "Protein Structure and Activity"

Workshop aim

The workshop will explore the need and progress in the measurement of higher-order protein structure, protein activity and the links between the two. An emphasis will be made on the state of the art and emerging measurement tools and approaches, including reference materials and methods, correlative measurements and computation, regulatory landscape and standardization needs for commercial development in industry.

The workshop is application agnostic and will focus on common challenges different application areas face to inform a relevant strategy for fostering measurements that will support predictable and measurable links between protein structure (from amino-acid sequences) and activity, prioritizing and developing measurement solutions and calibration services.

Agenda

The workshop includes four sessions:

Session 1: challenges to be addressed

• Links between structure and activity in healthcare and other areas
• Therapies and diagnostics – what is needed versus state of the art

Session 2: protein structure measurements

• Hierarchical structure measurements beyond primary structure analysis
• Links between sequence and structure: prediction, folding, first principles

Session 3: protein activity measurements

• Molecular recognition activities: antibody-antigen, protein-ligand, protein-lipid, enzymatic activities
• Folding dependent activities: encapsulation, transport, synthesis, amyloidosis

Session 4: standardization: now and future

• Reference materials and documentary standards
• Measurement tools, correlative measurements

Steering Committee