MEASURAND Mass fraction of GE
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
MEASURAND Mass fraction of total peptide related impurities
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
MEASURAND Mass fraction of GE
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO | -30.8 | 72.4 | ||
| LNE | -10.0 | 73.6 | ||
| NIM | 55.0 | 67.9 | ||
| BIPM | 2.5 | 72.9 | ||
| LGC | -43.6 | 67.2 | ||
| NMIJ | -3.2 | 69.3 | ||
| NRC | 15.4 | 73.4 | ||
| PTB | 31.7 | 70.6 | ||
| UME | -24.9 | 76.4 | ||
| HSA | 0.5 | 70.3 |
MEASURAND Mass fraction of total peptide related impurities
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO | -4.8 | 22.6 | ||
| LNE | 6.1 | 22.2 | ||
| NIM | -5.1 | 16.3 | ||
| BIPM | -8.9 | 16.5 | ||
| LGC | 35.6 | 19.5 | ||
| NMIJ | -5.1 | 17.0 | ||
| NRC | 11.2 | 26.8 | ||
| PTB | -11.7 | 16.6 | ||
| UME | 3.1 | 16.7 | ||
| HSA | -3.1 | 22.5 |
| Metrology area, Sub-field | Chemistry and Biology, Protein Analysis |
| Description | Peptide purity determination - Glycated hexapeptide of HbA1c (glcVHLTPE or GE) |
| Time of measurements | 2018 - 2020 |
| Status | Approved for equivalence |
| Final Reports of the comparisons | |
| Measurand | Mass fraction of glycated hexapeptide of HbA1c in the material (in mg/g) |
| Transfer device | Dedicated samples |
| Comparison type | Key Comparison |
| Consultative Committee | CCQM (Consultative Committee for Amount of Substance) |
| Conducted by | CCQM (Consultative Committee for Amount of Substance) |
| Comments | |
| Pilot institute |
BIPM
Bureau International des Poids et Mesures BIPM - International Organization |
| Contact person | R. Josephs +33 (0) 1 45 07 70 55 |
| Pilot laboratory | |
|---|---|
| BIPM |
Bureau International des Poids et Mesures, BIPM - International Organization, N/A |
| HSA |
Health Science Authority, Singapore, APMP |
| INMETRO |
Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM |
| LGC |
Laboratory of the Government Chemist, United Kingdom, EURAMET |
| LNE |
Laboratoire national de métrologie et d'essais, France, EURAMET |
| NIM |
National Institute of Metrology, China, APMP |
| NMIJ AIST |
National Metrology Institute of Japan, Japan, APMP |
| NRC |
National Research Council, Canada, SIM |
| PTB |
Physikalisch-Technische Bundesanstalt, Germany, EURAMET |
| UME |
TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET |
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MEASURAND Mass fraction of GE
The key comparison reference value xR and its associated standard uncertainty uR are based on the DerSimonian-Laird variance-weighted mean (DSL) of the participants' results.
xR = 628 mg/g uR = 12 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (uR2 + ui2)1/2.
MEASURAND Mass fraction of total peptide related impurities
The key comparison reference value xR and its associated standard uncertainty uR are based on the DerSimonian-Laird variance-weighted mean (DSL) of the participants' results.
xR = 45.4 mg/g uR = 4.2 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 (uR2 + ui2)1/2.
MEASURAND Mass fraction of GE
xi measurement value reported by participant laboratory i, Lab i
ui combined standard uncertainty of xi
| Labi | xi | ui |
| mg/g | mg/g | |
| INMETRO | 597.6 | 15.4 |
| LNE | 618.444 | 17.624 |
| NIM | 683.41 | 7.13 |
| BIPM | 630.9 | 14.5 |
| LGC | 584.8 | 6.4 |
| NMIJ | 625.2 | 6.3 |
| NRC | 643.8 | 14.9 |
| PTB | 660.1 | 7.5 |
| UME | 603.5 | 18.4 |
| HSA | 628.9 | 9.5 |
MEASURAND Mass fraction of total peptide related impurities
xi measurement value reported by participant laboratory i, Lab i
ui combined standard uncertainty of xi
| Labi | xi | ui |
| mg/g | mg/g | |
| INMETRO | 40.6 | 8.1 |
| LNE | 51.530 | 8.042 |
| NIM | 40.25 | 2.105 |
| BIPM | 36.5 | 1.8 |
| LGC | 81.0 | 6.1 |
| NMIJ | 40.3 | 2.7 |
| NRC | 56.6 | 11.1 |
| PTB | 33.7 | 1.3 |
| UME | 48.5 | 1.8 |
| HSA | 42.30 | 8 |
