CCQM-K115.2018
MEASURAND Mass fraction of Hexapeptide of HbA0’ (VE)
NOMINAL VALUE 600 mg/g
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
VE representing Hexapeptide of HbA0’
CCQM-K115.2018
MEASURAND Mass fraction of overall peptide-related impurities
NOMINAL VALUE 50 mg/g
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
VE representing Hexapeptide of HbA0’
CCQM-K115.2018
MEASURAND Mass fraction of Hexapeptide of HbA0’ (VE)
NOMINAL VALUE 600 mg/g
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO | 13 | 48 | ||
| LNE | 39 | 40 | ||
| NIM | 67 | 22 | ||
| BIPM | 13 | 24 | ||
| LGC | -20 | 21 | ||
| NMIJ | -1.6 | 29 | ||
| NRC | 17 | 28 | ||
| PTB | 32 | 24 | ||
| UME | -9.2 | 41 | ||
| GLHK | 24 | 52 | ||
| HSA | 21 | 24 |
VE representing Hexapeptide of HbA0’
CCQM-K115.2018
MEASURAND Mass fraction of overall peptide-related impurities
NOMINAL VALUE 50 mg/g
Degrees of equivalence represented by Di = (xI - xR) and its expanded uncertainty Ui at a 95 % level of confidence, both expressed in mg/g.
| LABi | Di | Uneg,i | Upos,i | |
|---|---|---|---|---|
mg/g |
mg/g |
mg/g |
||
| INMETRO | -26 | 23 | ||
| LNE | -9 | 73 | ||
| NIM | -30 | 18 | ||
| BIPM | -34 | 17 | ||
| LGC | 2 | 18 | ||
| NMIJ | -34 | 17 | ||
| NRC | -13 | 25 | ||
| PTB | -40 | 17 | ||
| UME | -23 | 18 | ||
| GLHK | -29 | 19 | ||
| HSA | -23 | 23 |
VE representing Hexapeptide of HbA0’
| Metrology area, Sub-field | Chemistry and Biology, Protein Analysis |
| Description | Peptide purity determination - Hexapeptide of HbA0 (VHLTPE or VE) |
| Time of measurements | 2018 - 2020 |
| Status | Approved for equivalence |
| Final Reports of the comparisons | |
| Measurand | Mass fraction of hexapeptide of HbA0 in the material (in mg/g) |
| Transfer device | Dedicated samples |
| Comparison type | Key Comparison |
| Consultative Committee | CCQM (Consultative Committee for Amount of Substance) |
| Conducted by | CCQM (Consultative Committee for Amount of Substance) |
| Pilot institute |
BIPM
Bureau International des Poids et Mesures BIPM - International Organization |
| Contact person | R. Josephs +33 (0) 1 45 07 70 55 |
| Pilot laboratory | |
|---|---|
| BIPM |
Bureau International des Poids et Mesures, BIPM - International Organization, N/A |
| GL |
Government Laboratory, Hong Kong, China, APMP |
| HSA |
Health Science Authority, Singapore, APMP |
| INMETRO |
Instituto Nacional de Metrologia, Qualidade e Tecnologia, Brazil, SIM |
| LGC |
Laboratory of the Government Chemist, United Kingdom, EURAMET |
| LNE |
Laboratoire national de métrologie et d'essais, France, EURAMET |
| NIM |
National Institute of Metrology, China, APMP |
| NMIJ AIST |
National Metrology Institute of Japan, Japan, APMP |
| NRC |
National Research Council, Canada, SIM |
| PTB |
Physikalisch-Technische Bundesanstalt, Germany, EURAMET |
| UME |
TÜBITAK Ulusal Metroloji Enstitüsü, Türkiye, EURAMET |
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CCQM-K115.2018
MEASURAND Mass fraction of Hexapeptide of HbA0’ (VE)
NOMINAL VALUE 600 mg/g
The determination of the key comparison reference value xR and its associated standard uncertainty uR is described from p. 28 and onwards in the CCQM-K115.2018 Final report.
xR = 613 mg/g uR = 10 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 ui.
CCQM-K115.2018
MEASURAND Mass fraction of overall peptide-related impurities
NOMINAL VALUE 50 mg/g
The determination of the key comparison reference value xR and its associated standard uncertainty uR is described from p. 25 and onwards in the CCQM-K115.2018 Final report.
xR = 53 mg/g uR = 8.6 mg/g
The degree of equivalence of laboratory i relative to the key comparison reference value xR is given by a pair of terms, both expressed in mg/g:
Di = (xi - xR) and its expanded uncertainty Ui at a 95 % level of confidence where Ui = 2 ui.
CCQM-K115.2018
MEASURAND Mass fraction of Hexapeptide of HbA0’ (VE)
NOMINAL VALUE 600 mg/g
xi measured mass fraction of VE as reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | u(xi) | |
| mg/g | mg/g | ||
| INMETRO | 626 | 22 | |
| LNE | 652.025 | 17.568 | |
| NIM | 679.5 | 5.0 | |
| BIPM | 625.5 | 6.5 | |
| LGC | 593.5 | 3.6 | |
| NMIJ | 611.4 | 10.4 | |
| NRC | 630.3 | 10.1 | |
| PTB | 645.4 | 6.6 | |
| UME | 603.8 | 17.8 | |
| GLHK | 637 | 24.1 | |
| HSA | 634.3 | 6.5 |
CCQM-K115.2018
MEASURAND Mass fraction of overall peptide-related impurities
NOMINAL VALUE 50 mg/g
xi measured mass fraction of overall peptide-related impurities as reported by laboratory i, Labi
ui combined standard uncertainty of xi
| Labi | xi | u(xi) | |
| mg/g | mg/g | ||
| INMETRO | 27.2 | 5.4 | |
| LNE | 44.192 | 35.354 | |
| NIM | 23 | 1.3 | |
| BIPM | 18.83 | 1.17 | |
| LGC | 54.6 | 3.0 | |
| NMIJ | 19.4 | 0.7 | |
| NRC | 40.2 | 9.0 | |
| PTB | 12.8 | 0.55 | |
| UME | 30 | 1.3 | |
| GLHK | 24 | 3.44 | |
| HSA | 29.8 | 7.75 |
